Guanabana which in Latin is called “Annona muricata” is a fruiting tree that is still classified as the Annonaceae family. One of the benefits taken from Guanabana is anti-cancer found in the leaves. However, traditional medicine uses all parts of the guanabana tree as medicine. Among them are treating malaria, inflammation, diabetes, parasites, and cancer.
Read on our article about the health benefits of guanabana. But before we see these benefits, lets first we see the important information about Guanabana.
Maybe you have never heard of Guanabana, but have heard a soursop. Soursop or Graviola is another name for guanabana. These are plants from South America and Caribbean. Now, this plant has been cultivated extensively because of its extraordinary benefits. Guanabana, he is still in the custard family. Its distribution area now includes Africa and southern Asia.
In addition to health benefits, guanabana is also famous for its soft and sharp flesh. In the traditional world, they have used this plant to treat various diseases such as malaria and even fever. Guanabana has been examined and examined for its superiority, and it is able to prevent cancer and other chronic diseases.
Here are some of the nutrients in guanabana:
- Contains potassium
- Contains Calcium
- Contains iron, and
While guanabana leaves and seeds contain large amounts of vitamins C and E. They are responsible for chronic diseases because they are famous for antioxidants.
In fact, more than 200 chemical compounds found in Guanabana. the most famous are alkaloids, phenols, and acetogenins. The most active phytochemistry in guanabana is found in leaves, seeds, and stems. These chemicals act against tumor parasites, cancer, inflammation, microbes, and insects.
Mechanism of Action
Pulp and skin of guanabana extract are useful for reducing inflammation in mice cells by reducing inflammatory mediators (COX, nitric oxide, TNF-α, and IL-1β). Guanabana leaf extract fights diabetes in mice and reduces blood sugar levels and influences insulin increase. This event occurs due to increased levels of antioxidants in the liver, reducing fat oxidation and preventing pancreatic β-cells.
In observations using a microscope, cell models in guanabana leaf extract showed antioxidant activity by scavenging free radical and cleaning it. This reduction of free radicals will prevent cell damage, DNA and protein. So, guanabana leaf extract is able and useful to reduce tumor cells and cancer by:
- Blocking energy production in cancer cells
- Increases programmed cell death (apoptosis) in cancer cells.
Guanabana leaf extract enhances apoptosis in cancer cells by:
- To activate mitochondrial-mediated pathways with NF-kB and Bcl-Xl
- Changing cancer cells in their structure
- Inspect the mitochondria of cancer cell membranes that cause damage to cancer cells.
- Prevents cell division thus avoiding cell proliferation
- Creating reactive oxygen species
Health Benefits of Guanabana
1. Guanabana Has Anti-Cancer Effects
Acetogenins in guanabana are very effective molecules to prevent and kill cancer cells. This phytochemical is produced in guanabana fruit, leaves, stems, bark and in guanabana seeds. Acetogenins are toxic to cancer cells and are capable of killing cancer cells, but they do not interfere with normal cells. Based on the anti-cancer, the health benefits of guanabana are as follows:
Guanabana Treating Colon Cancer
In a DB-RCT study involving 28 participants who had colorectal cancer, they were treated with guanabana extract. Patient blood samples were treated with guanabana leaf extract which is toxic to cancer cells, especially colon cancer. Guanabana leaf extract is useful for reducing cancerous tissue in the large intestine of mice.
Cancer cells in mice injected with guanabana extract were far less than those not given this injection. Acetogenins extract from guanabana seeds also functions as a poison against colon cancer and its strength is stronger than 10000 compared to chemotherapy.
Guanabana Combats Breast Cancer
The 66-year-old woman is able to stabilize breast cancer cells by consuming guanabana tea every day for 5 years. He also took medication with chemotherapy during consuming this tea.
Guanabana treats prostate cancer
Through apoptosis, mice that have prostate cancer can be treated with guanabana leaf extract. So, guanabana leaves reduce prostate tumor growth in mice. However, the content of acetogenins alone can kill mice due to poisoning.
Based on several studies, guanabana leaf extract is able to suppress prostate cancer cell growth.
Guanabana treats lung cancer
The content of acetogenins extract in guanabana leaves is able to kill lung cancer cells. This possibility occurs due to cancer cell apoptosis.
Guanabana can treat skin cancer
The use of guanabana leaf extract topically is able to stop skin tumors in mice, this is due to the high antioxidants in guanabana leaves. Guanabana leaf extract can function as a poison against skin cancer.
Guanabana is capable of treating liver cancer
Guanabana’s health benefits are killing liver cancer. This is the result of several studies conducted by medical experts. The method of treatment is possible with the mechanism of stress accumulation in cells and apoptosis.
Guanabana against pancreatic cancer
Guanabana stem and leaf extract are useful for reducing the tumor tissue of the pancreas by 50%. It is good for linking tumor growth and cancer.
Guanabana extract against cervical cancer
Furthermore, health benefits of guanabana leaf extract is reducing cervical cancer cells and prevents the growth of up to 80%. Annonacin is an acetogenin extract derived from soursop or guanabana seeds. He was able to increase cancer cell apoptosis by 65%. This is related to DNA damage due to cancer cells.
Guanabana is useful for treating leukemia
Guanabana is also beneficial for blood cancer or leukemia. Twigs, leaves, the root and guanabana seeds are able to induce apoptosis in leukemia cancer cells. It works by reducing the ability of cancer cells to survive.
2. Guanabana Has Antioxidant Effects
Antioxidants that come means plants like guanabana can prevent free radicals that cause cancer cells.
Based on research, the concentration of antioxidants in guanabana leaves, fruit can prevent oxidation damage to cells. Furthermore, guanabana flower extract also contains high antioxidants and can be used to preserve food oils.
Antioxidants in guanabana combine with polyphenols, tannins, carotenoids and anthocyanin content.
3. Guanabana against Pathogens
Guanabana skin, leaves, and seeds extracted indicate the presence of anti-microbes against various microorganisms including parasites, viruses, gram-positive, and gram-negative bacteria.
4. Guanabana is useful for fighting parasites
Lab test results, guanabana skin is more effective in treating leishmaniasis than obtaining modern chemistry. Acetogenins derived from guanabana leaves and seeds are very toxic to Leishmania and a worm.
Extracts from guanabana leaves show anti-parasitic activity, it can kill adult eggs, larvae and Haemonchus and can kill intestinal parasites in sheep.
Guanabana kills bacteria
The results of laboratory studies show that the extracts of guanabana seeds, leaves, roots and skin are useful against Pseudomonas aeruginosa, Staphylococcus aureus, Proteus vulgaris, Enterobacter aerogenes, Staphylococcus albus, Klebsiella pneumonia, Enterococcus faecalis, Vibrio cholerae, Escherichia coli, Bacillus subtilis, and Providencia stuartii bacteria.
Guanabana is useful for fighting viruses
Extracts from the guanabana stem are useful for preventing and suppressing the herpes simplex 1 virus in monkey kidneys. This extract is also useful for reducing herpes simplex virus 2 in human throat cells. In addition, guanabana extract also provides benefits for mushroom killing. It can prevent the growth of Candida albicans.
4. Guanabana prevents mosquito-borne diseases
The guanabana leaf extract can reduce malaria activity and can prolong life in mice. Guanabana leaf extract and seeds are very toxic to mosquito larvae which causes malaria, and dengue fever.
Isolated acetogenins are poisons to mosquito larvae because they prevent mitochondrial electron transport, resulting in stalled energy production in larval cells.
5. Guanabana is useful for reducing inflammation.
Skin and guanabana tree pulp are useful for reducing inflammation in mice because they reduce chemical mediators (COX and nitric oxide). Guanabana leaf extract reduces chronic inflammation in mice by reducing the levels of inflammatory mediators (nitric oxide, TNF-α and IL-1β)
6. Guanabana is useful for diabetes
In research conducted on rats, rat blood sugar can be reduced with guanabana leaf extract, not only this but this extract can also increase insulin.
Another function of guanabana leaf extracts is regenerating beta-cells in the mice with high sugar levels. The content of phenol in fruit extracts, skin, guanabana leaves is acting as a key enzyme against type 2 diabetes (α-amylase and α-glucosidase)
7. Guanabana is useful as an insect poison
Not only treat diseases in humans, but the health benefits of guanabana leaf extract can also kill adults and egg masses. It functions as a pesticide.
Acetogenins found in guanabana act as poison against plant pests such as green peach aphid, potato beetle, and so do the African cotton leafworm.